European Journal of Clinical Nutrition (2006) 60, 9–17. January 2006. doi:10.1038/sj.ejcn.1602261. © 2006 Nature Publishing GroupEffect of vitamin C on common cold: randomized controlled trial, S Sasazuki, S Sasaki, Y Tsubono, S Okubo, M Hayashi and S Tsugane.
To investigate the relationship between the common cold and vitamin C supplementation, Japanese researchers carried out a double-blind, 5-year randomized controlled trial in a village in Akita prefecture, one of the regions in Japan with the highest mortality from gastric cancer. Participants were those involved in annual screening programs for circulatory diseases conducted under the National Health and Welfare Services Law for the Aged, and diagnosed as having atrophic gastritis. Of the 439 eligible subjects, 144 and 161 were assigned to receive 50 or 500 mg of vitamin C, respectively, after protocol amendment. During the supplementation phase, 61 dropped out, and 244 completed the trial.They found that the total number of common colds (per 1000 person-months) was 21.3 and 17.1 for the low- and high-dose groups, respectively. After adjustment for several factors, the relative risks of suffering from a common cold three or more times during the survey period was 0.34 for the high-dose group. No apparent reduction was seen for the severity and duration of the common cold.
Penelitian RCT selama 5 tahun membuktikan bahwa suplementasi vitamin C dapat mengurangi frekuensi common cold, meskipun tidak mempengaruhi durasi dan beratnya penyakit.
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