Sterol nabati dalam jus jeruk dapat memperbaiki profil lipid dan menurunkan kadar CRP

Pernah saya menulis tentang sterol nabati yang bisa memperbaiki profil
lipid. Sterol nabati biasanya dicampur dalam lemak. Dalam penelitian ini
sterol nabati dicampurkan dalam jus jeruk rendah kalori.

Ternyata penambahan sterol nabati dapat menurunkan kadar kolesterol total
dan LDL sebesar hampir 10%, sekaligus meningkatkan kadar kolesterol HDL.
Selain memperbaiki profil lipid, kadar CRP (penanda proses inflamasi
kardiovaskuler) juga dapat diturunkan sampai 12%.

Hasil yang sangat positif dapat mendukung sterol nabati sebagai bahan
makanan sehat yang perlu dikonsumsi dalam diet sehari-hari. Namun masih
perlu dilakukan penelitian lebih mendalam tentang manfaat sterol nabati.
Abstract

American Journal of Clinical Nutrition October 2006, Vol. 84, No. 4,
756-761. Reduced-calorie orange juice beverage with plant sterols lowers
C-reactive protein concentrations and improves the lipid profile in human
volunteers. Sridevi Devaraj, Bryce C Autret and Ishwarlal Jialal.

Background: Dietary plant sterols effectively reduce LDL cholesterol when
incorporated into fat matrices. We showed previously that supplementation
with orange juice containing plant sterols (2 g/d) significantly reduced LDL
cholesterol. Inflammation is pivotal in atherosclerosis. High-sensitivity
C-reactive protein (hs-CRP), the prototypic marker of inflammation, is a
cardiovascular disease risk marker; however, there is a paucity of data on
the effect of plant sterols on CRP concentrations.

Objective: The aim of this study was to examine whether plant sterols affect
CRP concentrations and the lipoprotein profile when incorporated into a
reduced-calorie (50 calories/240 mL) orange juice beverage.

Design: Seventy-two healthy subjects were randomly assigned to receive a
reduced-calorie orange juice beverage either without (Placebo Bev) or with
(1 g/240 mL; Sterol Bev) plant sterols twice a day with meals for 8 wk.
Fasting blood was obtained at baseline and after 8 wk of Placebo Bev or
Sterol Bev supplementation.

Results: Sterol Bev supplementation significantly reduced total cholesterol
(5%; P < 0.01) and LDL cholesterol (9.4%; P < 0.001) compared with both
baseline and Placebo Bev (P < 0.05). HDL cholesterol increased significantly
with Sterol Bev (P < 0.02). No significant changes in triacylglycerol,
glucose, or liver function tests were observed with Sterol Bev. Sterol Bev
supplementation resulted in no significant change in vitamin E and
carotenoid concentrations. Sterol Bev supplementation resulted in a
significant reduction of CRP concentrations compared with baseline and
Placebo Bev (median reduction: 12%; P < 0.005).

Conclusion: Supplementation with a reduced-calorie orange juice beverage
containing plant sterols is effective in reducing CRP and LDL cholesterol
and could be incorporated into the dietary portion of therapeutic lifestyle
changes.